Best Arizona Cardinals fantasy performances of the last decade
Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.
Stacker compiled a ranking of the best Arizona Cardinals fantasy performances from 2016 to 2025 using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, wide receivers, and tight ends. Players are ranked based on standard fantasy scoring.
Best quarterback fantasy games#10. Kyler Murray, October 13, 2019
- Stats: 340 Passing Yards, 3 Passing TDs, 0 Interceptions, 32 Rushing Yards
- Game: ARI vs ATL, 34-33 Win
- Fantasy points: 28.80
#9. Kyler Murray, October 19, 2020
- Stats: 188 Passing Yards, 2 Passing TDs, 0 Interceptions, 74 Rushing Yards, 1 Rushing TDs
- Game: ARI vs DAL, 38-10 Win
- Fantasy points: 28.92
#8. Kyler Murray, November 15, 2020
- Stats: 245 Passing Yards, 1 Passing TDs, 1 Interceptions, 61 Rushing Yards, 2 Rushing TDs
- Game: ARI vs BUF, 32-30 Win
- Fantasy points: 29.90
#7. Kyler Murray, December 5, 2021
- Stats: 123 Passing Yards, 2 Passing TDs, 0 Interceptions, 59 Rushing Yards, 2 Rushing TDs
- Game: ARI vs CHI, 33-22 Win
- Fantasy points: 30.82
#6. Kyler Murray, September 20, 2020
- Stats: 286 Passing Yards, 1 Passing TDs, 1 Interceptions, 67 Rushing Yards, 2 Rushing TDs
- Game: ARI vs WAS, 30-15 Win
- Fantasy points: 32.14
#5. Kyler Murray, September 19, 2021
- Stats: 400 Passing Yards, 3 Passing TDs, 2 Interceptions, 31 Rushing Yards, 1 Rushing TDs
- Game: ARI vs MIN, 34-33 Win
- Fantasy points: 33.10
#4. Kyler Murray, December 20, 2020
- Stats: 406 Passing Yards, 3 Passing TDs, 1 Interceptions, 29 Rushing Yards, 1 Rushing TDs
- Game: ARI vs PHI, 33-26 Win
- Fantasy points: 33.14
#3. Kyler Murray, September 12, 2021
- Stats: 289 Passing Yards, 4 Passing TDs, 1 Interceptions, 20 Rushing Yards, 1 Rushing TDs
- Game: ARI vs TEN, 38-13 Win
- Fantasy points: 33.56
#2. Kyler Murray, October 25, 2020
- Stats: 360 Passing Yards, 3 Passing TDs, 1 Interceptions, 67 Rushing Yards, 1 Rushing TDs
- Game: ARI vs SEA, 37-34 (OT) Win
- Fantasy points: 37.10
#1. Kyler Murray, November 8, 2020
- Stats: 283 Passing Yards, 3 Passing TDs, 0 Interceptions, 106 Rushing Yards, 1 Rushing TDs
- Game: ARI vs MIA, 31-34 Loss
- Fantasy points: 37.92
#10. Kenyan Drake, October 19, 2020
- Stats: 164 Rushing Yards, 2 Rushing TDs
- Game: ARI vs DAL, 38-10 Win
- Fantasy points: 28.4
#9. David Johnson, December 4, 2016
- Stats: 84 Rushing Yards, 1 Rushing TDs, 91 Receiving Yards, 1 Receiving TDs
- Game: ARI vs WAS, 31-23 Win
- Fantasy points: 29.5
#8. David Johnson, December 24, 2016
- Stats: 95 Rushing Yards, 3 Rushing TDs, 41 Receiving Yards
- Game: ARI vs SEA, 34-31 Win
- Fantasy points: 29.6
#7. David Johnson, November 11, 2018
- Stats: 98 Rushing Yards, 1 Rushing TDs, 85 Receiving Yards, 1 Receiving TDs
- Game: ARI vs KAN, 14-26 Loss
- Fantasy points: 30.3
#6. Kenyan Drake, December 22, 2019
- Stats: 166 Rushing Yards, 2 Rushing TDs, 18 Receiving Yards
- Game: ARI vs SEA, 27-13 Win
- Fantasy points: 30.4
#5. David Johnson, October 6, 2016
- Stats: 157 Rushing Yards, 2 Rushing TDs, 28 Receiving Yards
- Game: ARI vs SFO, 33-21 Win
- Fantasy points: 30.5
#4. David Johnson, October 17, 2016
- Stats: 111 Rushing Yards, 3 Rushing TDs, 27 Receiving Yards
- Game: ARI vs NYJ, 28-3 Win
- Fantasy points: 31.8
#3. Chase Edmonds, October 20, 2019
- Stats: 126 Rushing Yards, 3 Rushing TDs, 24 Receiving Yards
- Game: ARI vs NYG, 27-21 Win
- Fantasy points: 33.0
#2. James Conner, November 7, 2021
- Stats: 96 Rushing Yards, 2 Rushing TDs, 77 Receiving Yards, 1 Receiving TDs
- Game: ARI vs SFO, 31-17 Win
- Fantasy points: 35.3
#1. Kenyan Drake, December 15, 2019
- Stats: 137 Rushing Yards, 4 Rushing TDs
- Game: ARI vs CLE, 38-24 Win
- Fantasy points: 38.6
#10. Larry Fitzgerald, October 6, 2016
- Stats: 81 Receiving Yards, 2 Receiving TDs, 6 Receptions, 8 Targets
- Game: ARI vs SFO, 33-21 Win
- Fantasy points: 20.1
#9. Larry Fitzgerald, September 11, 2016
- Stats: 81 Receiving Yards, 2 Receiving TDs, 8 Receptions, 10 Targets
- Game: ARI vs NWE, 21-23 Loss
- Fantasy points: 20.1
#8. DeAndre Hopkins, September 12, 2021
- Stats: 83 Receiving Yards, 2 Receiving TDs, 6 Receptions, 8 Targets
- Game: ARI vs TEN, 38-13 Win
- Fantasy points: 20.3
#7. Christian Kirk, October 19, 2020
- Stats: 86 Receiving Yards, 2 Receiving TDs, 2 Receptions, 3 Targets
- Game: ARI vs DAL, 38-10 Win
- Fantasy points: 20.6
#6. Larry Fitzgerald, September 25, 2017
- Stats: 149 Receiving Yards, 1 Receiving TDs, 13 Receptions, 15 Targets
- Game: ARI vs DAL, 17-28 Loss
- Fantasy points: 20.9
#5. DeAndre Hopkins, December 20, 2020
- Stats: 169 Receiving Yards, 1 Receiving TDs, 9 Receptions, 11 Targets
- Game: ARI vs PHI, 33-26 Win
- Fantasy points: 21.0
#4. DeAndre Hopkins, October 30, 2022
- Stats: 159 Receiving Yards, 1 Receiving TDs, 12 Receptions, 13 Targets
- Game: ARI vs MIN, 26-34 Loss
- Fantasy points: 21.9
#3. Marvin Harrison Jr., September 15, 2024
- Stats: 130 Receiving Yards, 2 Receiving TDs, 4 Receptions, 8 Targets
- Game: ARI vs LAR, 41-10 Win
- Fantasy points: 25.0
#2. Michael Wilson, December 7, 2025
- Stats: 142 Receiving Yards, 2 Receiving TDs, 11 Receptions, 16 Targets
- Game: ARI vs LAR, 17-45 Loss
- Fantasy points: 26.2
#1. Christian Kirk, November 10, 2019
- Stats: 138 Receiving Yards, 3 Receiving TDs, 6 Receptions, 10 Targets
- Game: ARI vs TAM, 27-30 Loss
- Fantasy points: 31.8
#10. Trey McBride, November 30, 2025
- Stats: 82 Receiving Yards, 1 Receiving TDs, 8 Receptions, 9 Targets
- Game: ARI vs TAM, 17-20 Loss
- Fantasy points: 14.2
#9. Trey McBride, December 3, 2023
- Stats: 89 Receiving Yards, 1 Receiving TDs, 8 Receptions, 9 Targets
- Game: ARI vs PIT, 24-10 Win
- Fantasy points: 14.9
#8. Trey McBride, October 29, 2023
- Stats: 95 Receiving Yards, 1 Receiving TDs, 10 Receptions, 14 Targets
- Game: ARI vs BAL, 24-31 Loss
- Fantasy points: 15.5
#7. Trey McBride, November 16, 2025
- Stats: 115 Receiving Yards, 1 Receiving TDs, 10 Receptions, 11 Targets
- Game: ARI vs SFO, 22-41 Loss
- Fantasy points: 17.5
#6. Dan Arnold, December 6, 2020
- Stats: 61 Receiving Yards, 2 Receiving TDs, 2 Receptions, 3 Targets
- Game: ARI vs LAR, 28-38 Loss
- Fantasy points: 18.1
#5. Trey McBride, December 28, 2024
- Stats: 123 Receiving Yards, 1 Receiving TDs, 12 Receptions, 16 Targets
- Game: ARI vs LAR, 9-13 Loss
- Fantasy points: 18.3
#4. Trey McBride, November 9, 2025
- Stats: 127 Receiving Yards, 1 Receiving TDs, 9 Receptions, 13 Targets
- Game: ARI vs SEA, 22-44 Loss
- Fantasy points: 18.7
#3. Trey McBride, October 19, 2025
- Stats: 74 Receiving Yards, 2 Receiving TDs, 10 Receptions, 13 Targets
- Game: ARI vs GNB, 23-27 Loss
- Fantasy points: 19.4
#2. Zach Ertz, November 21, 2021
- Stats: 88 Receiving Yards, 2 Receiving TDs, 8 Receptions, 9 Targets
- Game: ARI vs SEA, 23-13 Win
- Fantasy points: 20.8
#1. Trey McBride, December 14, 2025
- Stats: 134 Receiving Yards, 2 Receiving TDs, 12 Receptions, 13 Targets
- Game: ARI vs HOU, 20-40 Loss
- Fantasy points: 25.4
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