Best fantasy performances in Arizona Cardinals history

Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.

Stacker compiled a ranking of the best fantasy performances in Arizona Cardinals history using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, and wide receivers/tight ends across the franchise's history, based on standard fantasy scoring.

#5. Kyler Murray, December 20, 2020
- Stats: 406 Passing Yards, 3 Passing TDs, 1 Interceptions, 29 Rushing Yards, 1 Rushing TDs
- Game: ARI vs PHI, 33-26 Win
- Fantasy points: 33.14

#4. Kyler Murray, September 12, 2021
- Stats: 289 Passing Yards, 4 Passing TDs, 1 Interceptions, 20 Rushing Yards, 1 Rushing TDs
- Game: ARI vs TEN, 38-13 Win
- Fantasy points: 33.56

#3. Jake Plummer, November 22, 1998
- Stats: 251 Passing Yards, 2 Passing TDs, 1 Interceptions, 3 Rushing TDs
- Game: ARI vs WAS, 45-42 Win
- Fantasy points: 35.04

#2. Kyler Murray, October 25, 2020
- Stats: 360 Passing Yards, 3 Passing TDs, 1 Interceptions, 67 Rushing Yards, 1 Rushing TDs
- Game: ARI vs SEA, 37-34 (OT) Win
- Fantasy points: 37.1

#1. Kyler Murray, November 8, 2020
- Stats: 283 Passing Yards, 3 Passing TDs, 0 Interceptions, 106 Rushing Yards, 1 Rushing TDs
- Game: ARI vs MIA, 31-34 Loss
- Fantasy points: 37.92

#5. LeShon Johnson, September 22, 1996
- Stats: 214 Rushing Yards, 2 Rushing TDs
- Game: ARI vs NOR, 28-14 Win
- Fantasy points: 34.2

#4. James Conner, November 7, 2021
- Stats: 96 Rushing Yards, 2 Rushing TDs, 77 Receiving Yards, 1 Receiving TDs
- Game: ARI vs SFO, 31-17 Win
- Fantasy points: 35.3

#3. Ronald Moore, December 5, 1993
- Stats: 126 Rushing Yards, 4 Rushing TDs
- Game: PHO vs RAM, 38-10 Win
- Fantasy points: 36.6

#2. Kenyan Drake, December 15, 2019
- Stats: 137 Rushing Yards, 4 Rushing TDs
- Game: ARI vs CLE, 38-24 Win
- Fantasy points: 38.6

#1. David Johnson, December 20, 2015
- Stats: 187 Rushing Yards, 3 Rushing TDs, 42 Receiving Yards
- Game: ARI vs PHI, 40-17 Win
- Fantasy points: 40.9

#5. David Boston, December 3, 2000
- Stats: 184 Receiving Yards, 2 Receiving TDs, 9 Receptions, 15 Targets
- Game: ARI vs CIN, 13-24 Loss
- Fantasy points: 30.4

#4. Anquan Boldin, September 7, 2003
- Stats: 217 Receiving Yards, 2 Receiving TDs, 10 Receptions, 14 Targets
- Game: ARI vs DET, 24-42 Loss
- Fantasy points: 31.7

#3. Christian Kirk, November 10, 2019
- Stats: 138 Receiving Yards, 3 Receiving TDs, 6 Receptions, 10 Targets
- Game: ARI vs TAM, 27-30 Loss
- Fantasy points: 31.8

#2. Anquan Boldin, September 14, 2008
- Stats: 140 Receiving Yards, 3 Receiving TDs, 6 Receptions, 6 Targets
- Game: ARI vs MIA, 31-10 Win
- Fantasy points: 32.0

#1. Roy Green, September 17, 1989
- Stats: 166 Receiving Yards, 3 Receiving TDs, 8 Receptions, 11 Targets
- Game: PHO vs SEA, 34-24 Win
- Fantasy points: 34.6