In its nearly 250-year history, the United States has not only grown as a country with an ever-growing number of agencies and departments—it's also amassed an array of acronyms, some more memorable than others.
From POTUS to SCOTUS, FDA to FOIA, the people, offices, and agencies that form the foundation of America bring dozens of abbreviations to our nation's vocabulary. Whether to make sense of government-speak or navigate the alphabet soup of the daily news cycle, it helps to have a general understanding of them to stay informed.
Using data from governmental websites, encyclopedias, and news sources, Stacker has gathered a list of relevant offices and agencies—with corresponding clues to test your knowledge. How many can you identify off the top of your head? Follow the clues to find out.
Jeff Vanuga // Wikimedia Commons
1 / 100USDA
In 1862 Abraham Lincoln signed the act that created this agency, which had a mandate "to acquire and to diffuse … information on subjects connected with agriculture in the most general and comprehensive sense of that word."
A.H. Baldwin // Wikimedia Commons
2 / 100United States Department of Agriculture
From aiding American farmers to overseeing food safety, the USDA has a broad range of responsibilities. The USDA also subsidizes the Food and Nutrition Service, the federal agency that administers food stamps. Congress is currently negotiating the 2018 farm bill, which sets a five-year budget for the department.
Ken Hammond // Wikimedia Commons
3 / 100United States Department of Defense // Wikimedia Commons
4 / 100Department of Defense
Now dubbed the "Department of War" under a presidential order issued in September 2025, the Department of Defense is in charge of supplying the military forces necessary to defend the U.S. and ensure its safety. Former television personality and Army National Guard officer Peter Hegseth leads the department as the current Secretary of War.
James Tourtelotte // Wikimedia Commons
5 / 100DHS
Created in 2002 in the aftermath of the September 11 terrorist attacks, this department has the primary responsibility of ensuring that the U.S. is protected from security and safety threats, such as terrorist attacks and disasters.
U.S. Airforce // Wikimedia Commons
6 / 100Department of Homeland Security
Currently chaired by Kristi Noem, the Department of Homeland Security has more than 240,000 employees in more than 12 key offices and committees—including the Office of Intelligence and Analysis, U.S. Customs and Border Protection, the U.S. Coast Guard, and the U.S. Secret Service.
Jonathan McIntosh // flickr
7 / 100ICE
This is the second largest law enforcement organization in the U.S. and is operated by the Department of Homeland Security.
U.S. Immigrationa and Customs Enforcement // Wikimedia Commons
8 / 100Immigration and Customs Enforcement
In charge of enforcing immigration and customs law, ICE has been plastered across news headlines in 2025 as President Donald Trump seeks to fulfill a mass deportation agenda. As part of these efforts, ICE has conducted a series of high-profile raids in cities like Los Angeles, Miami, New York City, and more, sparking widespread backlash.
Steve Sapp // flickr
9 / 100CBP
Part of the Department of Homeland Security, this agency is a culmination of organizations with responsibilities of protecting the U.S. at its borders and ports of entries.
Brian Bell // flickr
10 / 100Customs and Border Protection
axonite / pixabay
11 / 100NSA
Officially created by President Harry S. Truman in 1952, this part of the American intelligence community has been one of the government's most secretive spy operations since the Cold War. It specializes in cryptology, the science of coding and decoding information.
National Security Agency // Wikimedia Commons
12 / 100National Security Administration
The National Security Agency operates under the Department of Defense, using mass information gathering to obtain data. In 2012, leaked documents from Edward Snowden detailed a wide range of secretive activities by this agency, including those meant to gather data on American citizens.
U.S. Army Materiel Command // Wikipedia Commons
13 / 100FBI
Created in 1908 by President Theodore Roosevelt and Attorney General Charles Bonaparte, this agency is one of the government's top law enforcement agencies. It also acts as an intelligence agency, reporting to both the attorney general and the director of national intelligence.
Federal Bureau of Investigation // Wikimedia Commons
14 / 100Federal Bureau of Investigation
The Federal Bureau of Investigation is headed by Kash Patel and operates 56 field offices throughout major U.S. cities, as well as 380 resident agencies in smaller cities. In 2018, a Department of Justice report put the agency's credibility into question for mishandling an investigation into Hillary Clinton in regard to classified documents stored on her email server.
Cora M. Highsmith // Wikimedia Commons
15 / 100CIA
President Harry S. Truman created this agency in 1947 when he signed the National Security Act. Today it's responsible for reporting national security intelligence to senior U.S. policymakers.
Fry1989 // Wikimedia Commons
16 / 100Central Intelligence Administration
John L. Ratcliffe is the current director of the Central Intelligence Agency.
David Wilson // flickr
17 / 100Tim Evanson // flickr
18 / 100Department of Housing and Urban Development
The Department of Housing and Urban Development was created in 1965 by President Lyndon B. Johnson. It is currently headed by Secretary Scott Turner, a former NFL player and Texas state representative.
Shane Peter // Wikimedia Commons
19 / 100HHS
This civilian department aims to protect the health of all Americans and provides essential human services.
Sarah Stierch // Wikimedia Commons
20 / 100Department of Health and Human Services
The Department of Health and Human Services is charged with implementing Medicare and Medicaid, as well as overseeing the Food and Drug Association, Centers for Disease Control and Prevention, and the National Institutes of Health.
William Cho // pixabay
21 / 100DOJ
This department is in charge of upholding federal laws, preventing crime, and protecting the public against any type of safety threat. It's also in charge of the federal prison system.
Department of Justice
The department administers law enforcement agencies such as the Drug Enforcement Agency; Bureau of Alcohol, Tobacco, and Firearms and Explosives; Federal Bureau of Investigation; and United States Marshals Service.
Dori // Wikimedia Commons
23 / 100EPA
This agency was established in 1970 to research, monitor, enforce, and set standards for environmental protection.
Donkey Hotey // flickr
24 / 100Environmental Protection Agency
stevepb // pixabay
25 / 100DEA
This law enforcement agency within the Department of Justice is charged with combating the sale and distribution of narcotics and other illegal drugs.
U.S. Government // Wikimedia Commons
26 / 100Drug Enforcement Administration
Created by President Nixon in 1973, the DEA maintains its mission to enforce its classification of marijuana as a Schedule I drug, even though multiple states and Washington D.C. have voted to legalize it for both recreational and medical use in recent years.
Free-Photos // pixabay
27 / 100FAA
This division of the U.S. Department of Transportation is in charge of regulating civil aviation and U.S. commercial space transportation, maintaining and operating air traffic control and navigation systems for both civil and military aircraft, and developing and administering programs relating to aviation safety and the National Airspace System.
Federal Aviation Administration // Wikimedia Commons
28 / 100Federal Aviation Administration
The Federal Aviation Administration was established by the Federal Aviation Act of 1958 and became a part of the Department of Transportation in 1967.
ahundt // pixabay
29 / 100FDIC
This independent agency was created by Congress in 1933 to maintain stability and public confidence in the nation's financial system.
Matthew Bisanz // Wikimedia Commons
30 / 100Federal Deposit Insurance Corporation
The Federal Deposit Insurance Corporation was created in response to the thousands of bank failures that occurred in the 1920s and 1930s. It insures deposits up to $250,000 and is funded by deposit insurance and earnings on investments in U.S. Treasury securities paid by banks and other savings and loan institutions.
DSW4 // Wikimedia Commons
31 / 100FEC
This regulatory agency was created in 1975 to promote confidence and participation in the democratic process.
U.S. Government // Wikimedia Commons
32 / 100Federal Election Commission
U.S. Army Corps of Engineers // flickr
33 / 100FEMA
This agency located within the Department of Homeland Security is responsible for managing the federal government's response to natural and manmade disasters.
Andrea Booher // Wikimedia Commons
34 / 100Federal Emergency Management Administration
The Federal Emergency Management Agency was founded in 1979 under President Jimmy Carter. In 2003, the agency became part of the U.S. Department of Homeland Security and was tasked with helping to ensure that first responders were able to deal with weapons of mass destruction.
The Official White House Photostream // Wikimedia Commons
35 / 100FOIA
This act gives the public the right to request access to records from any federal agency.
Cory Doctorow // flickr
36 / 100Freedom of Information Act
Congress enacted the Freedom of Information Act in 1967. It requires federal agencies to disclose any information requested under the act unless it falls under one of nine exemptions, such as personal privacy, national security, and law enforcement.
401K 2012 // flickr
37 / 100IRS
This government agency is in charge of enforcing the Internal Revenue Code.
Geraldshields11 // Wikimedia Commons
38 / 100Internal Revenue Service
President Abraham Lincoln and Congress created the position of Commissioner of Internal Revenue in 1862, enacting an income tax to cover war costs. Although it was repealed shortly after, the 16th Amendment gave Congress the authority to collect income tax in 1913. The bureau changed its name to the Internal Revenue Service in 1953.
Carol M. Highsmith // flickr
39 / 100LOC
This is the nation's oldest federal cultural institution, and it serves as the research arm of Congress.
U.S. Library of Congress // Wikimedia Commons
40 / 100Library of Congress
The Library of Congress is the largest library in the world, housing millions of books, recordings, photographs, newspapers, maps, and manuscripts. It's also in charge of the U.S. Copyright Office and serves as the main research arm of Congress.
U.S. Dept of Labor // Wikimedia Commons
41 / 100OSHA
This agency develops and enforces government standards that protect worker safety at U.S. job sites.
U.S. Government // Wikimedia Commons
42 / 100Occupational Safety and Health Administration
The Occupational Safety and Health Administration is headed by Loren Sweatt, deputy assistant secretary of Labor for Occupational Safety and Health. It is housed in the Department of Labor and answers to the secretary of labor. The Occupational Safety and Health Act of 1970 established the department, which offers certain protections to most private sector employers and their employees.
Alan Kotok // flickr
43 / 100PTO
This government agency has been around for more than 200 years, and is primarily responsible for trademark and patent applications.
Nick Youngston // Creative Commons Images
44 / 100Patent and Trademark Office
The Patent and Trademark Office not only grants U.S. patents and registers trademarks, they also advise the president, secretary of commerce, and government agencies on intellectual property policy, protection, and enforcement.
Michael Crane // Wikipedia Commons
45 / 100ROTC
Offered in U.S. colleges, universities, and high schools, this program trains students interested in serving as officers in the U.S. armed forces.
U.S. Navy Photo // Wikimedia Commons
46 / 100Reserve Officer Training Corps
Since World War II, the Reserve Officer Training Corps has been the biggest source of officers for the armed forces. Distinct ROTC programs exist for the army, navy, and air force.
nited States Air Force
47 / 100SSA
This independent federal agency provides income to people who are retired or have disabilities.
Public Domain // Wikimedia Commons
48 / 100Social Security Administration
The Social Security Administration is the result of the Social Security Act, which President Roosevelt signed in 1935. The program has a $12 billion budget and nearly 64,000 employees.
U.S. Department of Agriculture // flickr
49 / 100TANF
This government program helps needy families get on their feet and become self-sufficient.
U.S. Department of Agriculture // flickr
50 / 100Temporary Assistance for Needy Families
Temporary Assistance for Needy Families provides assistance to low-income families so that children can be cared for in their homes. It supports families so parents can prepare to apply for jobs, go to work, and maintain their marriages. It also encourages two-parent families.
Spencer Wing // pixabay
51 / 100TSA
This agency protects the nation's transportation networks from attack.
U.S. Department of Homeland Security // Wikimedia Commons
52 / 100Transportation Security Administration
The Transportation and Security Administration was founded in November 2001 in response to the September 11 terrorist attacks. Its nearly 60,000 employees sit under the Department of Homeland Security.
Brian Morales // Wikipedia Commons
53 / 100INS/USCIS
This agency administers the country's immigration system.
Immigration and Naturalization Service/United States Citizenship and Immigration Services
The United States Citizenship and Immigration Services is in charge of lawful immigration to the U.S. The agency is staffed by 19,000 government employees and contract workers. Created within the Department of Homeland Security, the USCIS succeeds the INS, which was abolished in 2003.
Jimmy C. Pan // Wikimedia Commons
55 / 100USAF
The mission of this government agency is to "fly, fight, and win… in air, space, and cyberspace."
Public Domain Pictures // pixabay
56 / 100United States Air Force
The United States Air Force is one of five branches of the military, headed by Chief of Staff David W. Allvin, who reports to Secretary of War Peter Hegseth. The Air Force was founded in 1907 as part of the Army, becoming independent in 1947 with the passage of the National Security Act.
U.S. Army // flickr
57 / 100USAID
This federal agency is in charge of foreign assistance to countries that are faced with disaster, poverty, and fledgling democracies.
U.S. Embassy // flickr
58 / 100United States Agency for International Development
The United States Agency for International Development was established in 1961 by President John F. Kennedy and offers assistance to developing countries. The agency has operations in more than 100 nations.
USPS
This department delivers mail and packages to every address in the U.S., as well as its territories and military installations around the world.
John Phelan // Wikimedia Commons
60 / 100United States Postal Service
Ryan C. Delcore // Wikimedia Commons
61 / 100VA
This department provides patient care and federal benefits to veterans and their dependents.
JeffOnWire // flickr
62 / 100Department of Veterans Affairs
The Department of Veterans Affairs took shape in 1930, when President Harry S. Truman signed Executive Order 5398. The administration boasts around 1,600 health care facilities.
M0TCX // Wikimedia Commons
63 / 100VOA
This government-funded, international, multimedia broadcast service provides news updates in more than 40 languages across the world.
Sarah Stierch // Wikimedia Commons
64 / 100Voice of America
Initially established in 1942 to counteract Nazi propaganda efforts, Voice of America now provides news, information, and cultural programming through traditional and digital media efforts.
Michael Stern // Wikimedia Commons
65 / 100ATF
This law enforcement agency within the Department of Justice is charged with protecting the public against violent criminals, criminal organizations, the illegal use of trafficking of firearms, and the illegal use and storage of explosives.
Bureau of Alcohol, Tobacco, Firearms and Explosives // Wikimedia Commons
66 / 100Bureau of Alcohol, Tobacco and Firearms
The Bureau of Alcohol, Tobacco, Firearms and Explosives has a staff of 5,113 employees, which includes 2,623 special agents, and its annual budget in 2017 was $1.258 billion.
Nick Youngson // Creative Commons Images
67 / 100CFPB
This government agency supervises banks, lenders, credit reporting agencies, and debt collection companies.
Ted Eytan // flickr
68 / 100Consumer Financial Protection Bureau
The Consumer Financial Protection Bureauk supervises U.S. financial institutions; it also works with companies to make credit card, mortgage, and loan disclosures transparent for consumers. The bureau was created when the Dodd-Frank Wall Street Reform and Consumer Protection Act passed in 2010.
CBO
This government office independently analyzes budgetary and economic issues to support Congress in their budgeting process.
Congressional Budget Office // Wikimedia Commons
70 / 100Congressional Budget Office
Daniel Schwen // Wikimedia Commons
71 / 100DOT
This agency is responsible for the nation's transportation systems and infrastructure.
U.S. Department of Transportation // Wikimedia Commons
72 / 100Department of Transportation
Congress established the Department of Transportation in 1966. It is currently led by Secretary of Transportation Sean Duffy.
UK DIFD // flickr
73 / 100CDC
This governmental organization is in charge of public health efforts to prevent and control infectious diseases, environmental threats, and workplace hazards.
Center for Disease Control and Protection // Wikimedia Commons
74 / 100Centers for Disease Control
The Centers for Disease Control was founded in 1946 and is part of the U.S. Department of Health and Human Services.
Michael Anderson // Wikimedia Commons
75 / 100NCES
This institution collects, analyzes, and reports data related to education in the U.S. and other nations.
National Center for Education Statistics // Wikimedia Commons
76 / 100National Center for Education Statistics
The National Center for Education Statistics is part of the U.S. Department of Education and the Institute of Education Sciences.
emlees // pixabay
77 / 100FHA
This agency provides mortgage insurance on loans made by government-approved lenders throughout the country.
U.S. Government // Wikimedia Commons
78 / 100Federal Housing Administration
The Federal Housing Administration insures mortgages on single and multi-family homes, as well as manufactured homes and hospitals. Founded in 1932, it has insured 47.5 million properties since its inception, making it the largest insurer of mortgages.
Ryan Lawler // Wikimedia Commons
79 / 100AlwaysAwakePR // Wikimedia Commons
80 / 100Federal Open Market Committee
The Federal Open Market Committee is a branch of the Federal Reserve Board, which determines whether monetary policy stays the same or changes course. The chairman of the FOMC is Jerome Powell who, by tradition, is also the chair of the Board of Governors.
Brad Perkins // Wikimedia Commons
81 / 100Geraldshields11 // Wikimedia Commons
82 / 100National Labor Relations Board
Employees who feel that their rights have been violated, or that their employer has engaged in unlawful behavior, can contact a regional office of the National Labor Relations Board. The board has five members appointed by the president and approved by the Senate; they act as a quasi-judicial body in deciding cases.
The White House // Wikimedia Commons
83 / 100NSC
This group meets and advises the president of the United States on national security and foreign policy matters.
Nicholas F. // Wikimedia Commons
84 / 100National Security Council
The National Security Council was established under President Harry S. Truman by the National Security Act of 1947. Chaired by the president, it regularly includes the vice president, secretary of state, secretary of the treasury, secretary of defense, and the assistant to the president.
Jericho // Wikimedia Commons
85 / 100Nick Youngson // Creative Common Images
86 / 100Office of Management and Budget
Chuck Patch // Wikimedia Commons
87 / 100U.S. Government // Wikimedia Commons
88 / 100Secret Service
The United States Secret Service was founded at the end of the American Civil War to combat counterfeiting of U.S. currency. It not only focuses on physically guarding the people who hold the highest offices in the U.S., but also helps the Department of Homeland Security protect American citizens from harm.
Marcin Cieslak // Wikipedia Commons
89 / 100CPSC
This independent federal agency protects U.S. consumers from potentially harmful or dangerous products sold domestically.
Pool Safety // Wikimedia Commons
90 / 100Consumer Product Safety Commission
pashminu // pixabay
91 / 100BLS
This group within the Department of Labor measures labor market activity, working conditions, and price changes in the economy.
United States Department of Labor // Wikimedia Commons
92 / 100Bureau of Labor Statistics
The mission of the Bureau of Labor Statistics is to measure labor market activity, as well as analyze and disseminate information to help public and private decision-making. The department is headed by a commissioner appointed by the president, who oversees 2,400 employees—mainly economists and statisticians.
itfhenry // Wikimedia Commons
93 / 100USFA
This division of the Federal Emergency Management Agency is the lead agency for fire data collection, public fire education, fire research, and fire service training.
skeeze // pixabay
94 / 100United States Fire Administration
skeeze // pixabay
95 / 100NCI
This is the U.S. government's principal agency for cancer research.
U.S. Government // Wikimedia Commons
96 / 100National Cancer Institute
Congress passed the National Cancer Act of 1937 to support cancer research and establish the National Cancer Institute. Its director leads the organization's 3,500-person team, which has a mission to save lives from the disease by supporting research across the country.
Scott Andrews // Wikimedia Commons
97 / 100NASA
This independent federal agency is in charge of the nation's space program.
Slammer111 // Wikimedia Commons
98 / 100National Aeronautics and Space Administration
The National Aeronautics and Space Administration is currently led by US Secretary of Transportation Sean Duffy, who leads a staff of more than 18,000 people charged with military aerospace research, development of space missions, and training of astronauts. NASA was created in 1958 in response to the Soviet Union's launch of its first satellite, Sputnik I.
Sarah Dietz // flickr
99 / 100DARPA
This agency is in charge of creating cutting-edge technologies and capabilities for national security.
DARPA // Wikimedia Commons
100 / 100Defense Advanced Research Projects Agency
Defense Advanced Research Projects Agency dates back to the 1957 launch of the Soviet satellite Sputnik I, when the U.S. resolved to be an innovator in technological advances. DARPA has 230 government employees who are responsible for nearly 250 research projects.