Best fantasy performances in Indianapolis Colts history

Every season in the NFL produces performances that feel less like a single game and more like statistical outliers — explosive outings where quarterbacks pile up passing yards, running backs break off long scoring runs, and receivers turn routine targets into multi-touchdown afternoons. These are the kinds of games that separate good fantasy weeks from historic ones.

Stacker compiled a ranking of the best fantasy performances in Indianapolis Colts history using data from Stathead. The list includes the highest single-game fantasy scores by quarterbacks, running backs, and wide receivers/tight ends across the franchise's history, based on standard fantasy scoring.

#5. Andrew Luck, September 11, 2016
- Stats: 385 Passing Yards, 4 Passing TDs, 0 Interceptions, 21 Rushing Yards
- Game: IND vs DET, 35-39 Loss
- Fantasy points: 35.5

#4. Andrew Luck, September 30, 2018
- Stats: 464 Passing Yards, 4 Passing TDs, 0 Interceptions, 11 Rushing Yards
- Game: IND vs HOU, 34-37 (OT) Loss
- Fantasy points: 35.66

#3. Peyton Manning, September 28, 2003
- Stats: 314 Passing Yards, 6 Passing TDs, 0 Interceptions
- Game: IND vs NOR, 55-21 Win
- Fantasy points: 36.66

#2. Peyton Manning, October 31, 2004
- Stats: 472 Passing Yards, 5 Passing TDs, 1 Interceptions
- Game: IND vs KAN, 35-45 Loss
- Fantasy points: 36.88

#1. Peyton Manning, September 23, 2001
- Stats: 421 Passing Yards, 4 Passing TDs, 2 Interceptions, 26 Rushing Yards, 1 Rushing TDs
- Game: IND vs BUF, 42-26 Win
- Fantasy points: 37.44

#5. Marshall Faulk, October 1, 1995
- Stats: 177 Rushing Yards, 3 Rushing TDs, 45 Receiving Yards
- Game: IND vs STL, 21-18 Win
- Fantasy points: 40.2

#4. Edgerrin James, October 15, 2000
- Stats: 219 Rushing Yards, 3 Rushing TDs
- Game: IND vs SEA, 37-24 Win
- Fantasy points: 40.8

#3. Joseph Addai, November 26, 2006
- Stats: 171 Rushing Yards, 4 Rushing TDs, 37 Receiving Yards
- Game: IND vs PHI, 45-21 Win
- Fantasy points: 44.8

#2. Jonathan Taylor, November 9, 2025
- Stats: 244 Rushing Yards, 3 Rushing TDs, 42 Receiving Yards
- Game: IND vs ATL, 31-25 (OT) Win
- Fantasy points: 46.6

#1. Jonathan Taylor, November 21, 2021
- Stats: 185 Rushing Yards, 4 Rushing TDs, 19 Receiving Yards, 1 Receiving TDs
- Game: IND vs BUF, 41-15 Win
- Fantasy points: 50.4

#5. Marvin Harrison, November 25, 2004
- Stats: 127 Receiving Yards, 3 Receiving TDs, 12 Receptions, 16 Targets
- Game: IND vs DET, 41-9 Win
- Fantasy points: 30.7

#4. Marvin Harrison, September 23, 2001
- Stats: 146 Receiving Yards, 3 Receiving TDs, 7 Receptions, 12 Targets
- Game: IND vs BUF, 42-26 Win
- Fantasy points: 32.6

#3. Reggie Wayne, October 29, 2006
- Stats: 138 Receiving Yards, 3 Receiving TDs, 10 Receptions, 11 Targets
- Game: IND vs DEN, 34-31 Win
- Fantasy points: 33.8

#2. Marvin Harrison, September 28, 2003
- Stats: 158 Receiving Yards, 3 Receiving TDs, 6 Receptions, 8 Targets
- Game: IND vs NOR, 55-21 Win
- Fantasy points: 33.8

#1. Marvin Harrison, November 11, 2001
- Stats: 174 Receiving Yards, 3 Receiving TDs, 9 Receptions, 12 Targets
- Game: IND vs MIA, 24-27 Loss
- Fantasy points: 35.4