Counties with highest COVID-19 infection rates in South Carolina

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May 21, 2022
Pollinator // Wikimedia Commons

Counties with highest COVID-19 infection rates in South Carolina

The vaccine deployment in December 2020 signaled a turning point in the COVID-19 pandemic. By the end of May 2021, 40% of the U.S. population was fully vaccinated. But as vaccination rates lagged over the summer, new surges of COVID-19 came, including Delta in the summer of 2021, and now the Omicron variant, which comprises the majority of cases in the U.S.

Researchers around the world have reported that Omicron is more transmissible than Delta, making breakthrough and repeat infections more likely.

The United States as of May 25 reached over 1 million COVID-19-related deaths and 83.6 million COVID-19 cases, according to Johns Hopkins University. Currently, 66.6% of the population is fully vaccinated, and 46.6% of vaccinated people have received booster doses.

Stacker compiled a list of the counties with highest COVID-19 infection rates in South Carolina using data from the U.S. Department of Health & Human Services and vaccination data from Covid Act Now. Counties are ranked by the highest infection rate per 100,000 residents within the week leading up to May 24, 2022. Cumulative cases per 100,000 served as a tiebreaker.

Keep reading to see whether your county ranks among the highest COVID-19 infection rates in your state.

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Upstateherd // Wikimedia Commons

#46. Allendale County, SC

- New cases per 100k in the past week: 0 (0 new cases, -100% change from previous week)
- Cumulative cases per 100k: 24,091 (2,093 total cases)
--- 17.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 276 (24 total deaths)
--- 20.7% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 59.0% (5,130 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#45. Saluda County, SC

- New cases per 100k in the past week: 15 (3 new cases, -50% change from previous week)
- Cumulative cases per 100k: 19,396 (3,971 total cases)
--- 33.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 381 (78 total deaths)
--- 9.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 30.6% (6,256 fully vaccinated)
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Brian Scott // Wikimedia Commons

#44. Abbeville County, SC

- New cases per 100k in the past week: 29 (7 new cases, +133% change from previous week)
- Cumulative cases per 100k: 27,162 (6,662 total cases)
--- 6.5% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 281 (69 total deaths)
--- 19.3% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 40.2% (9,861 fully vaccinated)
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ProfReader // Wikimedia Commons

#43. Marion County, SC

- New cases per 100k in the past week: 39 (12 new cases, -8% change from previous week)
- Cumulative cases per 100k: 27,974 (8,576 total cases)
--- 3.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 532 (163 total deaths)
--- 52.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.2% (15,089 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#42. Calhoun County, SC

- New cases per 100k in the past week: 41 (6 new cases, +100% change from previous week)
- Cumulative cases per 100k: 19,274 (2,805 total cases)
--- 33.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 419 (61 total deaths)
--- 20.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 41.4% (6,019 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#41. Laurens County, SC

- New cases per 100k in the past week: 43 (29 new cases, +71% change from previous week)
- Cumulative cases per 100k: 27,701 (18,696 total cases)
--- 4.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 437 (295 total deaths)
--- 25.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 38.8% (26,214 fully vaccinated)
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Calvin Beale // Wikimedia Commons

#40. Barnwell County, SC

- New cases per 100k in the past week: 43 (9 new cases, -18% change from previous week)
- Cumulative cases per 100k: 28,002 (5,843 total cases)
--- 3.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 494 (103 total deaths)
--- 42.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 56.7% (11,825 fully vaccinated)
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Morder // Wikimedia Commons

#39. Cherokee County, SC

- New cases per 100k in the past week: 47 (27 new cases, -4% change from previous week)
- Cumulative cases per 100k: 25,808 (14,788 total cases)
--- 11.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 562 (322 total deaths)
--- 61.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 34.5% (19,764 fully vaccinated)
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Pollinator // Wikimedia Commons

#38. Williamsburg County, SC

- New cases per 100k in the past week: 49 (15 new cases, -6% change from previous week)
- Cumulative cases per 100k: 28,227 (8,572 total cases)
--- 2.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 481 (146 total deaths)
--- 38.2% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.6% (17,483 fully vaccinated)
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Canva

#37. Chester County, SC

- New cases per 100k in the past week: 50 (16 new cases, -11% change from previous week)
- Cumulative cases per 100k: 31,479 (10,150 total cases)
--- 8.4% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 475 (153 total deaths)
--- 36.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.4% (14,971 fully vaccinated)
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Upstateherd // Wikimedia Commons

#36. Chesterfield County, SC

- New cases per 100k in the past week: 53 (24 new cases, +60% change from previous week)
- Cumulative cases per 100k: 25,980 (11,860 total cases)
--- 10.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 418 (191 total deaths)
--- 20.1% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 37.2% (16,985 fully vaccinated)
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Upstateherd // Wikimedia Commons

#35. Edgefield County, SC

- New cases per 100k in the past week: 55 (15 new cases, 0% change from previous week)
- Cumulative cases per 100k: 24,923 (6,794 total cases)
--- 14.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 260 (71 total deaths)
--- 25.3% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 60.6% (16,517 fully vaccinated)
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Canva

#34. Union County, SC

- New cases per 100k in the past week: 59 (16 new cases, +100% change from previous week)
- Cumulative cases per 100k: 28,430 (7,766 total cases)
--- 2.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 549 (150 total deaths)
--- 57.8% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 42.0% (11,482 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#33. Jasper County, SC

- New cases per 100k in the past week: 60 (18 new cases, +12% change from previous week)
- Cumulative cases per 100k: 19,759 (5,942 total cases)
--- 32.0% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 309 (93 total deaths)
--- 11.2% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 38.2% (11,477 fully vaccinated)
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Robert Thomas Mckenzie Jr // Wikimedia Commons

#32. Florence County, SC

- New cases per 100k in the past week: 61 (85 new cases, +52% change from previous week)
- Cumulative cases per 100k: 30,331 (41,946 total cases)
--- 4.4% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 458 (633 total deaths)
--- 31.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 55.4% (76,673 fully vaccinated)
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Ffuhr // Wikimedia Commons

#31. Hampton County, SC

- New cases per 100k in the past week: 62 (12 new cases, +500% change from previous week)
- Cumulative cases per 100k: 26,199 (5,036 total cases)
--- 9.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 447 (86 total deaths)
--- 28.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 64.4% (12,377 fully vaccinated)
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Jud McCranie // Wikimedia Commons

#30. Darlington County, SC

- New cases per 100k in the past week: 65 (43 new cases, +87% change from previous week)
- Cumulative cases per 100k: 28,494 (18,982 total cases)
--- 1.9% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 467 (311 total deaths)
--- 34.2% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.1% (32,731 fully vaccinated)
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Canva

#29. Spartanburg County, SC

- New cases per 100k in the past week: 67 (214 new cases, +22% change from previous week)
- Cumulative cases per 100k: 29,886 (95,571 total cases)
--- 2.9% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 484 (1,548 total deaths)
--- 39.1% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 44.1% (141,100 fully vaccinated)
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Festiva76 // Wikimedia Commons

#28. Aiken County, SC

- New cases per 100k in the past week: 68 (116 new cases, +9% change from previous week)
- Cumulative cases per 100k: 24,511 (41,883 total cases)
--- 15.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 256 (437 total deaths)
--- 26.4% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.5% (79,408 fully vaccinated)
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Upstateherd // Wikimedia Commons

#27. Colleton County, SC

- New cases per 100k in the past week: 72 (27 new cases, -25% change from previous week)
- Cumulative cases per 100k: 23,728 (8,940 total cases)
--- 18.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 587 (221 total deaths)
--- 68.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 48.8% (18,380 fully vaccinated)
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Upstateherd // Wikimedia Commons

#26. Anderson County, SC

- New cases per 100k in the past week: 72 (145 new cases, +41% change from previous week)
- Cumulative cases per 100k: 28,718 (58,170 total cases)
--- 1.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 494 (1,000 total deaths)
--- 42.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 40.7% (82,455 fully vaccinated)
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Canva

#25. Georgetown County, SC

- New cases per 100k in the past week: 75 (47 new cases, +15% change from previous week)
- Cumulative cases per 100k: 25,534 (16,005 total cases)
--- 12.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 362 (227 total deaths)
--- 4.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 54.9% (34,388 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#24. Greenwood County, SC

- New cases per 100k in the past week: 80 (57 new cases, +307% change from previous week)
- Cumulative cases per 100k: 32,006 (22,664 total cases)
--- 10.2% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 435 (308 total deaths)
--- 25.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 48.4% (34,270 fully vaccinated)
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Upstateherd // Wikimedia Commons

#23. Fairfield County, SC

- New cases per 100k in the past week: 81 (18 new cases, -10% change from previous week)
- Cumulative cases per 100k: 26,961 (6,025 total cases)
--- 7.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 479 (107 total deaths)
--- 37.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 65.1% (14,539 fully vaccinated)
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Ammodramus // Wikimedia Commons

#22. Lee County, SC

- New cases per 100k in the past week: 83 (14 new cases, +133% change from previous week)
- Cumulative cases per 100k: 25,469 (4,286 total cases)
--- 12.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 570 (96 total deaths)
--- 63.8% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 48.4% (8,143 fully vaccinated)
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Farrargirl // Wikimedia Commons

#21. McCormick County, SC

- New cases per 100k in the past week: 85 (8 new cases, +60% change from previous week)
- Cumulative cases per 100k: 23,798 (2,252 total cases)
--- 18.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 423 (40 total deaths)
--- 21.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 59.2% (5,600 fully vaccinated)
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Upstateherd // Wikimedia Commons

#20. Clarendon County, SC

- New cases per 100k in the past week: 86 (29 new cases, +45% change from previous week)
- Cumulative cases per 100k: 26,093 (8,805 total cases)
--- 10.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 471 (159 total deaths)
--- 35.3% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.5% (16,690 fully vaccinated)
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Ammodramus // Wikimedia Commons

#19. Orangeburg County, SC

- New cases per 100k in the past week: 86 (74 new cases, +10% change from previous week)
- Cumulative cases per 100k: 27,269 (23,499 total cases)
--- 6.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 487 (420 total deaths)
--- 39.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 56.3% (48,494 fully vaccinated)
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Canva

#18. Greenville County, SC

- New cases per 100k in the past week: 87 (455 new cases, +24% change from previous week)
- Cumulative cases per 100k: 33,196 (173,793 total cases)
--- 14.3% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 384 (2,010 total deaths)
--- 10.3% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 55.8% (292,252 fully vaccinated)
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KudzuVine // Wikimedia Commons

#17. Pickens County, SC

- New cases per 100k in the past week: 89 (113 new cases, +6% change from previous week)
- Cumulative cases per 100k: 36,430 (46,224 total cases)
--- 25.4% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 499 (633 total deaths)
--- 43.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 47.0% (59,605 fully vaccinated)
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Brian Stansberry // Wikimedia Commons

#16. Oconee County, SC

- New cases per 100k in the past week: 94 (75 new cases, +36% change from previous week)
- Cumulative cases per 100k: 30,703 (24,423 total cases)
--- 5.7% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 431 (343 total deaths)
--- 23.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 45.3% (36,045 fully vaccinated)
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Itsbrandoyo // Wikimedia Commons

#15. Berkeley County, SC

- New cases per 100k in the past week: 97 (222 new cases, +30% change from previous week)
- Cumulative cases per 100k: 23,019 (52,462 total cases)
--- 20.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 197 (450 total deaths)
--- 43.4% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 52.6% (119,895 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#14. Bamberg County, SC

- New cases per 100k in the past week: 107 (15 new cases, +36% change from previous week)
- Cumulative cases per 100k: 24,605 (3,461 total cases)
--- 15.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 533 (75 total deaths)
--- 53.2% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 51.5% (7,250 fully vaccinated)
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Calvin Beale // Wikimedia Commons

#13. Marlboro County, SC

- New cases per 100k in the past week: 107 (28 new cases, +155% change from previous week)
- Cumulative cases per 100k: 30,278 (7,908 total cases)
--- 4.2% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 402 (105 total deaths)
--- 15.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 44.3% (11,580 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#12. Dillon County, SC

- New cases per 100k in the past week: 112 (34 new cases, +278% change from previous week)
- Cumulative cases per 100k: 32,032 (9,763 total cases)
--- 10.3% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 472 (144 total deaths)
--- 35.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 45.0% (13,710 fully vaccinated)
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NatalieMaynor // Wikimedia Commons

#11. Newberry County, SC

- New cases per 100k in the past week: 112 (43 new cases, +16% change from previous week)
- Cumulative cases per 100k: 34,854 (13,398 total cases)
--- 20.0% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 507 (195 total deaths)
--- 45.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 52.9% (20,320 fully vaccinated)
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Calatayudboy // Wikimedia Commons

#10. Lancaster County, SC

- New cases per 100k in the past week: 115 (113 new cases, +30% change from previous week)
- Cumulative cases per 100k: 25,904 (25,389 total cases)
--- 10.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 287 (281 total deaths)
--- 17.5% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.9% (45,953 fully vaccinated)
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Canva

#9. Beaufort County, SC

- New cases per 100k in the past week: 119 (228 new cases, +37% change from previous week)
- Cumulative cases per 100k: 22,776 (43,758 total cases)
--- 21.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 198 (381 total deaths)
--- 43.1% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 66.4% (127,534 fully vaccinated)
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Connor401 // Wikimedia Commons

#8. York County, SC

- New cases per 100k in the past week: 123 (347 new cases, +15% change from previous week)
- Cumulative cases per 100k: 27,977 (78,610 total cases)
--- 3.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 243 (682 total deaths)
--- 30.2% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 50.1% (140,804 fully vaccinated)
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Pollinator // Wikimedia Commons

#7. Kershaw County, SC

- New cases per 100k in the past week: 131 (87 new cases, +19% change from previous week)
- Cumulative cases per 100k: 32,622 (21,710 total cases)
--- 12.3% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 392 (261 total deaths)
--- 12.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 59.2% (39,382 fully vaccinated)
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Ralph Hightower // Wikimedia Commons

#6. Lexington County, SC

- New cases per 100k in the past week: 146 (435 new cases, +19% change from previous week)
- Cumulative cases per 100k: 32,470 (97,004 total cases)
--- 11.8% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 292 (872 total deaths)
--- 16.1% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 56.0% (167,367 fully vaccinated)
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Pollinator // Wikimedia Commons

#5. Sumter County, SC

- New cases per 100k in the past week: 155 (165 new cases, +24% change from previous week)
- Cumulative cases per 100k: 26,485 (28,265 total cases)
--- 8.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 369 (394 total deaths)
--- 6.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.4% (61,295 fully vaccinated)
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Lazyksaw // Wikimedia Commons

#4. Dorchester County, SC

- New cases per 100k in the past week: 160 (261 new cases, +61% change from previous week)
- Cumulative cases per 100k: 34,756 (56,586 total cases)
--- 19.6% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 305 (496 total deaths)
--- 12.4% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 53.8% (87,633 fully vaccinated)
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Canva

#3. Charleston County, SC

- New cases per 100k in the past week: 168 (693 new cases, +16% change from previous week)
- Cumulative cases per 100k: 27,692 (113,927 total cases)
--- 4.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 231 (949 total deaths)
--- 33.6% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 66.0% (271,653 fully vaccinated)
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Canva

#2. Richland County, SC

- New cases per 100k in the past week: 171 (710 new cases, +30% change from previous week)
- Cumulative cases per 100k: 29,894 (124,288 total cases)
--- 2.9% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 228 (947 total deaths)
--- 34.5% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 59.8% (248,470 fully vaccinated)
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Pollinator // Wikimedia Commons

#1. Horry County, SC

- New cases per 100k in the past week: 182 (643 new cases, +32% change from previous week)
- Cumulative cases per 100k: 27,727 (98,177 total cases)
--- 4.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 328 (1,161 total deaths)
--- 5.7% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.0% (201,849 fully vaccinated)

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