Counties with highest COVID-19 infection rates in South Carolina

Written by:
November 17, 2022
Ralph Hightower // Wikimedia Commons

Counties with highest COVID-19 infection rates in South Carolina

The vaccine deployment in December 2020 signaled a turning point in the COVID-19 pandemic. By the end of May 2021, 40% of the U.S. population was fully vaccinated. But as vaccination rates lagged over the summer, new surges of COVID-19 came, including Delta in the summer of 2021, and now the Omicron variant, which comprises the majority of cases in the U.S.

Researchers around the world have reported that Omicron is more transmissible than Delta, making breakthrough and repeat infections more likely.

The United States as of Nov. 16 reached over 1 million COVID-19-related deaths and 98.1 million COVID-19 cases, according to Johns Hopkins University. Currently, 68.6% of the population is fully vaccinated, and 10.1% of vaccinated people have received the most recently available bivalent booster doses.

Stacker compiled a list of the counties with highest COVID-19 infection rates in South Carolina using data from the U.S. Department of Health & Human Services and vaccination data from Covid Act Now. Counties are ranked by the highest infection rate per 100,000 residents within the week leading up to Nov. 10, 2022. Cumulative cases per 100,000 served as a tiebreaker.

Keep reading to see whether your county ranks among the highest COVID-19 infection rates in your state.

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Bill Fitzpatrick // Wikimedia Commons

#46. Saluda County, SC

- New cases per 100k in the past week: 10 (2 new cases, -50% change from previous week)
- Cumulative cases per 100k: 21,409 (4,383 total cases)
--- 36.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 405 (83 total deaths)
--- 11.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 31.3% (6,407 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#45. Calhoun County, SC

- New cases per 100k in the past week: 21 (3 new cases, -40% change from previous week)
- Cumulative cases per 100k: 23,143 (3,368 total cases)
--- 31.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 419 (61 total deaths)
--- 15.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 42.6% (6,203 fully vaccinated)
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Upstateherd // Wikimedia Commons

#44. Clarendon County, SC

- New cases per 100k in the past week: 24 (8 new cases, -47% change from previous week)
- Cumulative cases per 100k: 30,458 (10,278 total cases)
--- 9.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 489 (165 total deaths)
--- 35.1% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 50.6% (17,062 fully vaccinated)
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Upstateherd // Wikimedia Commons

#43. Allendale County, SC

- New cases per 100k in the past week: 35 (3 new cases, +200% change from previous week)
- Cumulative cases per 100k: 27,106 (2,355 total cases)
--- 19.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 276 (24 total deaths)
--- 23.8% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 60.7% (5,275 fully vaccinated)
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Calvin Beale // Wikimedia Commons

#42. Barnwell County, SC

- New cases per 100k in the past week: 43 (9 new cases, -10% change from previous week)
- Cumulative cases per 100k: 31,209 (6,512 total cases)
--- 7.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 503 (105 total deaths)
--- 39.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.7% (12,045 fully vaccinated)
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Jud McCranie // Wikimedia Commons

#41. Darlington County, SC

- New cases per 100k in the past week: 44 (29 new cases, +38% change from previous week)
- Cumulative cases per 100k: 31,949 (21,284 total cases)
--- 4.9% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 497 (331 total deaths)
--- 37.3% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 50.3% (33,485 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#40. Greenwood County, SC

- New cases per 100k in the past week: 44 (31 new cases, -6% change from previous week)
- Cumulative cases per 100k: 35,880 (25,407 total cases)
--- 6.8% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 452 (320 total deaths)
--- 24.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.3% (34,884 fully vaccinated)
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Canva

#39. Georgetown County, SC

- New cases per 100k in the past week: 45 (28 new cases, -3% change from previous week)
- Cumulative cases per 100k: 29,767 (18,658 total cases)
--- 11.4% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 378 (237 total deaths)
--- 4.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 56.2% (35,214 fully vaccinated)
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Pollinator // Wikimedia Commons

#38. Williamsburg County, SC

- New cases per 100k in the past week: 46 (14 new cases, +8% change from previous week)
- Cumulative cases per 100k: 32,172 (9,770 total cases)
--- 4.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 494 (150 total deaths)
--- 36.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 58.7% (17,820 fully vaccinated)
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Ammodramus // Wikimedia Commons

#37. Lee County, SC

- New cases per 100k in the past week: 48 (8 new cases, +33% change from previous week)
- Cumulative cases per 100k: 28,560 (4,806 total cases)
--- 15.0% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 582 (98 total deaths)
--- 60.8% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.5% (8,333 fully vaccinated)
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ProfReader // Wikimedia Commons

#36. Marion County, SC

- New cases per 100k in the past week: 49 (15 new cases, -12% change from previous week)
- Cumulative cases per 100k: 32,864 (10,075 total cases)
--- 2.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 548 (168 total deaths)
--- 51.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 50.2% (15,394 fully vaccinated)
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Upstateherd // Wikimedia Commons

#35. Colleton County, SC

- New cases per 100k in the past week: 50 (19 new cases, -17% change from previous week)
- Cumulative cases per 100k: 28,325 (10,672 total cases)
--- 15.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 597 (225 total deaths)
--- 64.9% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 50.2% (18,910 fully vaccinated)
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Robert Thomas Mckenzie Jr // Wikimedia Commons

#34. Florence County, SC

- New cases per 100k in the past week: 51 (71 new cases, +9% change from previous week)
- Cumulative cases per 100k: 34,869 (48,221 total cases)
--- 3.8% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 484 (669 total deaths)
--- 33.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 56.6% (78,268 fully vaccinated)
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Ffuhr // Wikimedia Commons

#33. Hampton County, SC

- New cases per 100k in the past week: 52 (10 new cases, +67% change from previous week)
- Cumulative cases per 100k: 29,680 (5,705 total cases)
--- 11.6% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 447 (86 total deaths)
--- 23.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 65.7% (12,634 fully vaccinated)
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Brian Stansberry // Wikimedia Commons

#32. Oconee County, SC

- New cases per 100k in the past week: 52 (41 new cases, +2% change from previous week)
- Cumulative cases per 100k: 34,843 (27,716 total cases)
--- 3.7% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 458 (364 total deaths)
--- 26.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.4% (36,916 fully vaccinated)
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Pollinator // Wikimedia Commons

#31. Sumter County, SC

- New cases per 100k in the past week: 54 (58 new cases, +12% change from previous week)
- Cumulative cases per 100k: 31,097 (33,187 total cases)
--- 7.4% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 391 (417 total deaths)
--- 8.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 58.8% (62,700 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#30. Laurens County, SC

- New cases per 100k in the past week: 58 (39 new cases, -22% change from previous week)
- Cumulative cases per 100k: 32,131 (21,686 total cases)
--- 4.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 455 (307 total deaths)
--- 25.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 39.7% (26,811 fully vaccinated)
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Canva

#29. Charleston County, SC

- New cases per 100k in the past week: 62 (256 new cases, +16% change from previous week)
- Cumulative cases per 100k: 32,124 (132,160 total cases)
--- 4.4% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 241 (991 total deaths)
--- 33.4% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 68.1% (279,976 fully vaccinated)
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Canva

#28. Beaufort County, SC

- New cases per 100k in the past week: 64 (122 new cases, +23% change from previous week)
- Cumulative cases per 100k: 26,519 (50,949 total cases)
--- 21.0% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 209 (401 total deaths)
--- 42.3% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 70.9% (136,125 fully vaccinated)
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Upstateherd // Wikimedia Commons

#27. Anderson County, SC

- New cases per 100k in the past week: 64 (130 new cases, -3% change from previous week)
- Cumulative cases per 100k: 32,638 (66,111 total cases)
--- 2.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 520 (1,054 total deaths)
--- 43.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 41.6% (84,334 fully vaccinated)
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Brian Scott // Wikimedia Commons

#26. Abbeville County, SC

- New cases per 100k in the past week: 65 (16 new cases, +45% change from previous week)
- Cumulative cases per 100k: 29,828 (7,316 total cases)
--- 11.2% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 289 (71 total deaths)
--- 20.2% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 41.6% (10,197 fully vaccinated)
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Upstateherd // Wikimedia Commons

#25. Edgefield County, SC

- New cases per 100k in the past week: 66 (18 new cases, +20% change from previous week)
- Cumulative cases per 100k: 28,734 (7,833 total cases)
--- 14.5% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 268 (73 total deaths)
--- 26.0% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 62.7% (17,081 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#24. Jasper County, SC

- New cases per 100k in the past week: 67 (20 new cases, +122% change from previous week)
- Cumulative cases per 100k: 22,791 (6,854 total cases)
--- 32.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 319 (96 total deaths)
--- 11.9% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 39.7% (11,932 fully vaccinated)
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Canva

#23. Spartanburg County, SC

- New cases per 100k in the past week: 68 (217 new cases, -1% change from previous week)
- Cumulative cases per 100k: 34,365 (109,894 total cases)
--- 2.3% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 496 (1,587 total deaths)
--- 37.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 45.1% (144,372 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#22. Dillon County, SC

- New cases per 100k in the past week: 69 (21 new cases, +24% change from previous week)
- Cumulative cases per 100k: 36,133 (11,013 total cases)
--- 7.6% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 489 (149 total deaths)
--- 35.1% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.3% (14,107 fully vaccinated)
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Itsbrandoyo // Wikimedia Commons

#21. Berkeley County, SC

- New cases per 100k in the past week: 71 (162 new cases, +16% change from previous week)
- Cumulative cases per 100k: 27,599 (62,901 total cases)
--- 17.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 204 (464 total deaths)
--- 43.6% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 54.4% (123,876 fully vaccinated)
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Morder // Wikimedia Commons

#20. Cherokee County, SC

- New cases per 100k in the past week: 73 (42 new cases, +20% change from previous week)
- Cumulative cases per 100k: 30,206 (17,308 total cases)
--- 10.1% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 571 (327 total deaths)
--- 57.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 35.3% (20,225 fully vaccinated)
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Festiva76 // Wikimedia Commons

#19. Aiken County, SC

- New cases per 100k in the past week: 75 (128 new cases, +27% change from previous week)
- Cumulative cases per 100k: 28,610 (48,887 total cases)
--- 14.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 261 (446 total deaths)
--- 27.9% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 48.2% (82,414 fully vaccinated)
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Canva

#18. Greenville County, SC

- New cases per 100k in the past week: 77 (403 new cases, -6% change from previous week)
- Cumulative cases per 100k: 37,546 (196,568 total cases)
--- 11.8% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 397 (2,077 total deaths)
--- 9.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.3% (300,147 fully vaccinated)
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Pollinator // Wikimedia Commons

#17. Horry County, SC

- New cases per 100k in the past week: 81 (288 new cases, +11% change from previous week)
- Cumulative cases per 100k: 32,479 (115,002 total cases)
--- 3.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 349 (1,236 total deaths)
--- 3.6% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 58.5% (207,292 fully vaccinated)
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NatalieMaynor // Wikimedia Commons

#16. Newberry County, SC

- New cases per 100k in the past week: 83 (32 new cases, -24% change from previous week)
- Cumulative cases per 100k: 40,216 (15,459 total cases)
--- 19.7% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 541 (208 total deaths)
--- 49.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 54.2% (20,836 fully vaccinated)
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Farrargirl // Wikimedia Commons

#15. McCormick County, SC

- New cases per 100k in the past week: 85 (8 new cases, +60% change from previous week)
- Cumulative cases per 100k: 27,296 (2,583 total cases)
--- 18.7% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 433 (41 total deaths)
--- 19.6% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 60.9% (5,765 fully vaccinated)
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Bill Fitzpatrick // Wikimedia Commons

#14. Bamberg County, SC

- New cases per 100k in the past week: 85 (12 new cases, +140% change from previous week)
- Cumulative cases per 100k: 29,056 (4,087 total cases)
--- 13.5% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 540 (76 total deaths)
--- 49.2% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 52.5% (7,385 fully vaccinated)
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Upstateherd // Wikimedia Commons

#13. Fairfield County, SC

- New cases per 100k in the past week: 85 (19 new cases, +36% change from previous week)
- Cumulative cases per 100k: 31,798 (7,106 total cases)
--- 5.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 501 (112 total deaths)
--- 38.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 67.1% (14,997 fully vaccinated)
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Connor401 // Wikimedia Commons

#12. York County, SC

- New cases per 100k in the past week: 86 (243 new cases, +2% change from previous week)
- Cumulative cases per 100k: 32,258 (90,639 total cases)
--- 4.0% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 252 (709 total deaths)
--- 30.4% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 52.5% (147,451 fully vaccinated)
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Canva

#11. Chester County, SC

- New cases per 100k in the past week: 87 (28 new cases, +4% change from previous week)
- Cumulative cases per 100k: 36,599 (11,801 total cases)
--- 9.0% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 487 (157 total deaths)
--- 34.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 47.6% (15,335 fully vaccinated)
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Calvin Beale // Wikimedia Commons

#10. Marlboro County, SC

- New cases per 100k in the past week: 88 (23 new cases, +130% change from previous week)
- Cumulative cases per 100k: 35,799 (9,350 total cases)
--- 6.6% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 429 (112 total deaths)
--- 18.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 46.2% (12,079 fully vaccinated)
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KudzuVine // Wikimedia Commons

#9. Pickens County, SC

- New cases per 100k in the past week: 95 (120 new cases, +19% change from previous week)
- Cumulative cases per 100k: 40,798 (51,766 total cases)
--- 21.5% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 517 (656 total deaths)
--- 42.8% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 47.9% (60,831 fully vaccinated)
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Canva

#8. Richland County, SC

- New cases per 100k in the past week: 96 (400 new cases, +39% change from previous week)
- Cumulative cases per 100k: 36,270 (150,797 total cases)
--- 8.0% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 239 (992 total deaths)
--- 34.0% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 63.2% (262,938 fully vaccinated)
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Lazyksaw // Wikimedia Commons

#7. Dorchester County, SC

- New cases per 100k in the past week: 98 (160 new cases, +28% change from previous week)
- Cumulative cases per 100k: 40,948 (66,667 total cases)
--- 21.9% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 329 (535 total deaths)
--- 9.1% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 55.2% (89,941 fully vaccinated)
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Upstateherd // Wikimedia Commons

#6. Chesterfield County, SC

- New cases per 100k in the past week: 110 (50 new cases, +32% change from previous week)
- Cumulative cases per 100k: 30,811 (14,065 total cases)
--- 8.3% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 447 (204 total deaths)
--- 23.5% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 38.5% (17,582 fully vaccinated)
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Calatayudboy // Wikimedia Commons

#5. Lancaster County, SC

- New cases per 100k in the past week: 116 (114 new cases, +115% change from previous week)
- Cumulative cases per 100k: 30,222 (29,621 total cases)
--- 10.0% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 297 (291 total deaths)
--- 18.0% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 49.5% (48,529 fully vaccinated)
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Ammodramus // Wikimedia Commons

#4. Orangeburg County, SC

- New cases per 100k in the past week: 118 (102 new cases, +79% change from previous week)
- Cumulative cases per 100k: 32,456 (27,969 total cases)
--- 3.4% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 501 (432 total deaths)
--- 38.4% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.7% (49,709 fully vaccinated)
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Pollinator // Wikimedia Commons

#3. Kershaw County, SC

- New cases per 100k in the past week: 128 (85 new cases, +70% change from previous week)
- Cumulative cases per 100k: 38,791 (25,816 total cases)
--- 15.5% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 409 (272 total deaths)
--- 13.0% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 60.8% (40,442 fully vaccinated)
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Canva

#2. Union County, SC

- New cases per 100k in the past week: 157 (43 new cases, +59% change from previous week)
- Cumulative cases per 100k: 33,303 (9,097 total cases)
--- 0.8% less cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 578 (158 total deaths)
--- 59.7% more deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 43.1% (11,773 fully vaccinated)
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Ralph Hightower // Wikimedia Commons

#1. Lexington County, SC

- New cases per 100k in the past week: 175 (523 new cases, +70% change from previous week)
- Cumulative cases per 100k: 38,705 (115,631 total cases)
--- 15.2% more cases per 100k residents than South Carolina
- Cumulative deaths per 100k: 309 (923 total deaths)
--- 14.6% less deaths per 100k residents than South Carolina
- Population that is fully vaccinated: 57.5% (171,813 fully vaccinated)

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